University Directory

Kamal Jonnalagadda, PhD

Professor

Director of Pharmaceutics Graduate Program

S. Kamal Jonnalagadda PhD

Department

Office

Pharmacology and Toxicology Center 245

Phone

215-596-8942
Contact

Dr. Jonnalagadda earned a PhD from the University of Nebraska and a BPharm from BIT, in India. He studies the design, characterization, and modeling of polymeric biomaterials for specific pharmaceutical applications, including solid dosage forms and biodegradable polymeric implants for macromolecular drug delivery and tissue engineering.

    • BPharm, Birla-India
    • PhD, Nebraska

  • Patents

    • "Biocompatible Hybrid Molecular Brushes and Methods of Making Same." Alexander Sidorenko, Sriramakamal Jonnalagadda, Manasi Chawathe. U.S. Patent Pub. No. US 2020/0109243 A1. Publication date April 9, 2020.

    Publications

    • S. Sivasankaran, S. Jonnalagadda. "Advances in Controlled Release Hormonal Technologies for Contraception: A Review of Existing Devices, Underlying Mechanisms, and Future Directions." 330. 797-811, 2021.
    • P. Ramalingam, P. Ganesan, D. S. Prabakaran, P. Gupta, S. Jonnalagadda, K. Govindarajan, R. Vishnu, K. Sivalingam, S. Sodha, D Choi & Y. Ko. "Lipid Nanoparticles Improve the Uptake of α-Asarone Into the Brain Parenchyma: Formulation, Characterization, In Vivo Pharmacokinetics, and Brain Delivery." AAPS PharmSciTech, 21(8), 1-11, 2020.
    • R. Nagarkar, M Singh, H. Nguyen, S. Jonnalagadda. "A Comprehensive Assessment on Microneedle Technology." Journal of Drug Delivery Science and Technology, 59 (101923), 2020.
    • M Chawathe, D Asheghali, S Minko, S Jonnalagadda, A Sidorenko. "Adaptive Hybrid Molecular Brushes Composed of Chitosan, Polylactide, and Poly(N-vinyl pyrrolidone) for Support and Guiding Human Dermal Fibroblasts." ACS Applied Biomaterials, 3(7), 4118-4127, 2020.
    • M Singh, S. Jonnalagadda. "Advances in Bioprinting Using Additive Manufacturing." European Journal of Pharmaceutical Sciences, 143, 1-13, 2020.
    • S. Kaur, S Sivasankaran, E Wambolt, S. Jonnalagadda. "Determinants of Zero-Order Release Kinetics from Acetaminophen-Layered Suglet® Pellets, Wurster-Coated with Plasticized Aquacoat® ECD (Ethyl Cellulose Dispersion)." International Journal of Pharmaceutics, 573, (118873), 2020.
    • M. Chawathe, A. Patel, S. Jonnalagadda, Alexander Sidorenko. "Design of Hybrid Molecular Brushes with Reversible Surface Adaptability on Exposure to Specific Solvents." Biointerphases. 2018 Aug 12;13(4):041006.
    • C. Javiya, S. Jonnalagadda. "Physicochemical Characterization of Spray-Dried PLGA/PEG Microspheres, and Preliminary Assessment of Biological Response." In Press, Drug Dev. & Industrial Pharmacy. Jan 2016.
    • N. Panda, A. Biswas, K. Pramanik, S. Jonnalagadda. "Enhanced Osteogenic Potential of Human Mesenchymal Stem Cells on Electrospun Nanofibrous Scaffolds Prepared from Eri-Tasar Silk Fibroin." Journal of Biomedical Materials, Part B., 103(5), 971-982, 2015.
    • N.N. Panda, S. Jonnalagadda, K. Pramanik. "Development and Evaluation of Cross-Linked Collagen-Hydroxyapatite Scaffolds for Tissue Engineering." In Press, J. Biomat. Sci. Polym. Ed. (2013)
    • A. Rane, S. Jonnalagadda, Z. Li. "On-Column Refolding of Bone Morphogenetic Protein-2 Using Cation Exchange Resin." Protein expression and purification, 90, 135-140, 2013.
    • K.S.Gokhale, S. Jonnalagadda. "Preparation and Evaluation of Sustained Release Infliximab Microspheres." Accepted for publication in: PDA Journal of Pharmaceutical Science and Technology, 67(3), 255-266, 2013.
    • V. Waknis, S. Jonnalagadda. "Novel Poly-DL-Lactide-Polycaprolactone Copolymer Based Flexible Drug Delivery System for Sustained Release of Ciprofloxacin." Drug Delivery, 18(4), 236-245, 2011.
    • J Gupta, C. Nunes, S. Vyas, S. Jonnalagadda. "Prediction of Solubility Parameters and Miscibility of Pharmaceutical Compounds by Molecular Dynamics Simulations." J. Phy. Chem B, 115 (2014-2023), 2011.
    • P. Park, M.Makoid, S.Jonnalagadda. "The Design of Flexible Ciprofloxacin-Loaded PLGA Implants Using a Reversed Phase Separation/Coacervation Method." European J. Pharm. Biopharm., 77, 233-239, 2011.
    • K Shahani, S Jonnalagadda, H Handa, G Mao and J Panyam. "Phospholipid Nanoparticles: Process Optimization Using Fractional Factorial Design and Atomic Force Microscopy." J. Biomed. Nanotech., 3(4), 394-400, 2007.
    • V. Swaminathan, R. Tchao, S. Jonnalagadda. "Physical Characterization of Semi-Porous Poly (Lactide)/Poly (Ethylene Glycol) Membranes for Tissue Engineering." J. Biomat. Sci. Polym. Ed. 18(10), 1321-1333, 2007.
    • K. Garkhal, S. Verma, S. Jonnalagadda, N. Kumar. "Fast Degradable Poly (L-Lactide-Co-E-Caprolactone) Microspheres for Tissue Engineering." Synthesis, characterization, and degradation behavior. J. Polym. Sci. Part. A. Polym. Chem. 45(13), 2755-2764, 2007.
    • R.G.Forcino, S. Jonnalagadda. "The Effect of Fabrication Methods on the Mechanical and Thermal Properties of PLGA Scaffolds." J. of Applied Polym. Sci., 104(2), 944-949, 2007.
    • P.Park, S. Jonnalagadda. "Predictors of Glass Transition in the Biodegradable Poly-Lactide and Poly-Lactide-Co-Glycolide Polymers." J. of Applied Polym Sci., 100(3), 1983-87, 2006.
    • R. L. Graves, M.C. Makoid, S. Jonnalagadda. "The Effect of Coencapsulation of Bovine Insulin with Cyclodextrins in Ethylcellulose Microcapsules." J. Microencapsul. 22(6), 661-670, 2005.
    • S. Jonnalagadda, D.H.Robinson. "Effect of Thickness and PEG Addition on the Hydrophilic Degradation of PLLA." J. Biomat. Sci. Polym. Ed., 15(10), 1317-26, 2004.
    • S. Jonnalagadda, D.H.Robinson. "Effect of the Inclusion of PEG on the Solid-State Properties and Drug Release from Polylactic Acid Films and Microcapsules." J. Applied Polym. Sci., 93(5), 2025-30, 2004.
    • S. Jonnalagadda, D. H. Robinson. "A Bioresorbable Polylactide Delivery System for Diffusional and Osmotic Controlled Drug Delivery." AAPS Pharm. Sci. Tech., 1:E29, 2000.

  • The research focus in Dr. Jonnalagadda's laboratory is the design, characterization, and the modeling of polymeric biomaterials for specific pharmaceutical applications. Applications include:

    1. Solid dosage forms: polymorphic transitions as a function of excipient concentration, storage (or aging), and during the different stages of drug formulation, such as mixing, granulation, drying and compression.
    2. Biodegradable polymeric implants for macromolecular drug delivery and tissue engineering.